Division of Integrative Physiology

Director　　　　 Toshihiko Yada, PhD
　　

Director, Center for Integrative Physiology, Kansai Electric Power Medical Research Institute
Chief Director, Division of Integrative Physiology, Kansai Electric Power Medical Research Institute
Visiting Professor, Division of Systemic Physiology, Kobe University Graduate School of Medicine

Research Summary

The division aims to clarify the mechanism for controlling feeding, glucose metabolism and energy metabolism, based on “meal/gut-brain linkage” including the role of vagal afferent nerve. From this perspective, we aim to uncover the cause for type 2 diabetes, obesity and abnormal feeding and to establish/develop novel treatment of these diseases.
The following subjects are ongoing.

Selected Recent Publications

  • Ito K, Dezaki K, Yoshida M, Yamada H, Miura R, Rita RS, Ookawara S, Tabei K, Kawakami M, Hara K, Morishita Y, Yada T, Kakei M.: Endogenous α2A-adrenoceptor-operated sympathoadrenergic tones attenuate insulin secretion via cAMP/TRPM2 signaling. Diabetes 66(3): 699-709, 2017.
  • Nakata M, Yamamoto S, Okada T, Yada T.: AAV-mediated IL-10 gene transfer counteracts inflammation in the hypothalamic arcuate nucleus and obesity induced by high-fat diet. Neuropeptides 62: 87-92, 2017.
  • Santoso P, Nakata M, Ueta Y, Yada T.: Suprachiasmatic vasopressin to paraventricular oxytocin neurocircuit in the hypothalamus relays light reception to inhibition of feeding behavior. Am J Physiol Endocrinol Metab. Feb 7, 2017. [Epub ahead of print]
  • Santoso P, Nakata M, Shiizaki K, Boyang Z, Parmila K, Otgon-Uul Z, Hashimoto K, Satoh T, Mori M, Kuro-O M, Yada T.: Fibroblast growth factor 21, assisted by elevated glucose, activates paraventricular nucleus NUCB2/Nesfatin-1 neurons to produce satiety under fed states. Scientific Rep. 7: 45819, 2017.
  • Suyama S, Lei W, Kubota N, Kadowaki T, Yada T.: Adiponectin at physiological level glucose-independently enhances inhibitory postsynaptic current onto NPY neurons in the hypothalamic arcuate nucleus. Neuropeptides 65: 1-9, 2017.
  • Sasanuma H, Nakata M, Kumari P, Nakae J, Yada T.: PDK1-FoxO1 pathway in AgRP neurons of arcuate nucleus promotes bone formation via GHRH-GH-IGF1 axis. Mol Metab. 6(5): 428-439, 2017.
  • Iwasaki Y, Goswami C, Yada T.: Glucagon-like peptide-1 and insulin synergistically activate vagal afferent neurons. Neuropeptides 65: 77-82, 2017.
  • Suyama S, Ralevski A, Liu ZW, Dietrich MO, Yada T, Simonds SE, Cowley MA, Gao XB, Diano S, Horvath TL.: Plasticity of calcium-permeable AMPA glutamate receptors in Pro-opiomelanocortin neurons. Elife 6: e25755,
    2017.
  • Loh K, Shi Y, Walters S, Bensellam M, Lee K, Dezaki K, Nakata M, Ip CK, Chan J, Gurzov E, Thomas H, Waibel M, Cantley J, Kay T, Yada T, Laybutt R, Grey S, Herzog H.: Inhibition of Y1 receptor signaling improves islet transplant outcome. Nature Communications 8(1): 490, 2017.
  • Ota M, Yoshida S, Nakata M, Yada T, Kunugi H.: The effects of adjunctive intranasal oxytocin in patients with schizophrenia. Postgrad Med. 130(1): 122-128, 2017.
  • Iwasaki Y, Sendo M, Dezaki K, Hira T, Sato T, Nakata M, Goswami C, Aoki R, Arai T, Kumari P, Hayakawa M, Masuda C, Okada T, Hara H, Drucker DJ, Yamada Y, Tokuda M, Yada T.: GLP-1 release and vagal afferent activation mediate the beneficial metabolic and chronotherapeutic effects of D-allulose. Nature Communications 9(1): 113, 2018.
  • Okamoto S, Sato T, Tateyama M, Kageyama H, Maejima Y, Nakata M, Hirako S, Matsuo T, Kyaw S, Shiuchi T, Toda C, Sedbazar U, Saito K, Asgar NF, Zhang B, Yokota S, Kobayashi K, Foufelle F, Ferré P, Nakazato M, Masuzaki H, Shioda S, Yada T, Kahn BB, Minokoshi Y.: Activation of AMPK-regulated CRH neurons in the PVH is sufficient and necessary to induce dietary preference for carbohydrate over fat. Cell Rep. 22(3): 706-721, 2018.
  • Ando A, Gantulga D, Nakata M, Maekawa F, Dezaki K, Ishibashi S, Yada T.: Weaning stage hyperglycemia induces glucose-insensitivity in arcuate POMC neurons and hyperphagia in type 2 diabetic GK rats. Neuropeptides 68:49-56, 2018.
  • Goswami C, Iwasaki Y, Yada T.: Short chain fatty acids suppress food intake by activating vagal afferent neurons. J Nutr Biochem. 57:130-135, 2018.
  • Kumari P, Nakata M, Zhang BY, Otgon-Uul Z, Yada T. GLP-1 receptor agonist liraglutide exerts central action to induce β-cell proliferation through medulla to vagal pathway in mice. Biochem Biophys Res Commun. 499(3):618-625, 2018.
  • Zhang B, Nakata M, Lu M, Nakae J, Okada T, Ogawa W, Yada T. Protective role of AgRP neuron’s PDK1 against salt-induced hypertension. Biochem Biophys Res Commun. 500(4):910-916, 2018.

Members

Director Toshihiko Yada, PhD
Researcher Goswami Chayon, PhD
Researcher Chacrabati Rakhi, PhD
Researcher Yifei Yang
Researcher Lei Wang