Division of Diabetes and Endocrinology Yutaka Seino Distinguished Center for Diabetes Research

Research Summary

The division has been investigating the pathophysiology of type 2 diabetes, especiallyin the Asian population, as well as the pharmacological and nutritional therapeutics for prevention and management of the disease and its complications.
Our research interests include secretion and action of the incretins, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which enhance insulin secretion from the pancreas glucose-dependently to control glucose metabolism after meals. We also examine the clinical safety and efficacy of incretin-based therapies in the management of type 2 diabetes.

 

Selected Recent Publications

Writer	Publications
Yabe D, Seino Y, Fukushima M, Seino S.	“β cell dysfunction versus insulin resistance in the pathogenesis of type 2 diabetes in East Asians” Current Diabetes Reports (2015)15(6): 602-6011.
Yabe D, Kuroe A, Watanabe K, Iwasaki M, Hamasaki A, Hamamoto Y, Harada N, Yamane S, Lee S, Murotani K, Deacon CF, Holst JJ, Hirano T, Inagaki N, Kurose T, Seino Y.	“Early phase glucagon and insulin secretory abnormalities, but not incretin secretion, are similarly responsible for hyperglycemia after ingestion of nutrients.” Journal of Diabetes and Its Complications (2015) 29:413-421.
Yabe D, Kuwata H, Kaneko M, Ito C, Nishikino R, Murorani K, Kurose T, Seino Y.	“Use of the Japanese health insurance claims database to assess the risk of acute pancreatitis in patients with diabetes: Comparison of DPP-4 inhibitors with other oral anti-diabetic drugs.” Diabetes, Obesity and Metabolism (2015) 17(4):430-434.
Seino Y, Yabe D.	“GIP and GLP-1: Incretin actions beyond pancreas.” Journal of Diabetes Investigation (2013) 4(2): 108-130.
Iwasaki M, Hoshian F, Tsuji T, Hirose N, Matsumoto T, Kitatani N, Sugawara K, Usui R, Kuwata H, Sugizaki K, Kitamoto Y, Fujiwara S, Watanabe K, Hyo T, Kurose T, Seino Y, Yabe D.	“Predicting efficacy of DPP-4 inhibitors in patients with type 2 diabetes: association of HbA1c reduction with serum eicosapentaenoic acid and docosahexaenoic acid levels.” Journal of Diabetes Investigation (2012) 3(5): 464-467.

Members

Director	Daisuke Yabe, MD, PhD
Deputy Director
Researcher	Nagaaki Tanaka, MD
Researcher	Takuro Yamaguchi
Researcher	Shinobu Shimizu
Researcher	Hiroaki Eto
Researcher	Ryosuke Matsuki
Researcher	Takayuki Endo
Researcher	Mayuka Sakaguchi
Researcher	Shuichi Fujiwara, MD
Researcher	Yui Sakuramachi, MD
Researcher	Shinji Ueno, MD
Researcher	Saki Okamoto, MD
Researcher	Yoshikazu Hirasawa
Researcher	Noboru Makabe
Researcher	Yuka Moriguchi
Visiting Scholar