Division of Diabetes and Endocrinology Yutaka Seino Distinguished Center for Diabetes Research

Director     Daisuke Yabe, MD, PhD

Deputy Director General, Kansai Electric Power Medical Research Institute
Director, Center for Diabetes, Endocrinology and Metabolism, Kansai Electric Power Hospital
Chief Director, Center for Metabolism and Clinical Nutrition,Kansai Electric Power Hospital
Visiting Associate Professor, Division of Molecular and Metabolic Medicine, Kobe University Graduate School of Medicine

Research Summary

The division has been investigating the pathophysiology of type 2 diabetes, especiallyin the Asian population, as well as the pharmacological and nutritional therapeutics for prevention and management of the disease and its complications.
Our research interests include secretion and action of the incretins, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which enhance insulin secretion from the pancreas glucose-dependently to control glucose metabolism after meals. We also examine the clinical safety and efficacy of incretin-based therapies in the management of type 2 diabetes.


Selected Recent Publications

Writer Publications
Yabe D, Seino Y, Fukushima M, Seino S. “β cell dysfunction versus insulin resistance in the pathogenesis of type 2 diabetes in East Asians” Current Diabetes Reports (2015)15(6): 602-6011.
Yabe D, Kuroe A, Watanabe K, Iwasaki M, Hamasaki A, Hamamoto Y, Harada N, Yamane S, Lee S, Murotani K, Deacon CF, Holst JJ, Hirano T, Inagaki N, Kurose T, Seino Y. “Early phase glucagon and insulin secretory abnormalities, but not incretin secretion, are similarly responsible for hyperglycemia after ingestion of nutrients.” Journal of Diabetes and Its Complications (2015) 29:413-421. 
Yabe D, Kuwata H, Kaneko M, Ito C, Nishikino R, Murorani K, Kurose T, Seino Y. “Use of the Japanese health insurance claims database to assess the risk of acute pancreatitis in patients with diabetes: Comparison of DPP-4 inhibitors with other oral anti-diabetic drugs.” Diabetes, Obesity and Metabolism (2015) 17(4):430-434.
Seino Y, Yabe D. “GIP and GLP-1: Incretin actions beyond pancreas.” Journal of Diabetes Investigation (2013) 4(2): 108-130.
Iwasaki M, Hoshian F, Tsuji T, Hirose N, Matsumoto T, Kitatani N, Sugawara K, Usui R, Kuwata H, Sugizaki K, Kitamoto Y, Fujiwara S, Watanabe K, Hyo T, Kurose T, Seino Y, Yabe D. “Predicting efficacy of DPP-4 inhibitors in patients with type 2 diabetes: association of HbA1c reduction with serum eicosapentaenoic acid and docosahexaenoic acid levels.” Journal of Diabetes Investigation (2012) 3(5): 464-467.


Director Daisuke Yabe, MD, PhD
Deputy Director
Researcher Nagaaki Tanaka, MD
Researcher Takuro Yamaguchi
Researcher Shinobu Shimizu
Researcher Hiroaki Eto
Researcher Ryosuke Matsuki
Researcher Takayuki Endo
Researcher Mayuka Sakaguchi
Researcher Shuichi Fujiwara, MD
Researcher Yui Sakuramachi, MD
Researcher Shinji Ueno, MD
Researcher Saki Okamoto, MD
Researcher Yoshikazu Hirasawa
Researcher Noboru Makabe
Researcher Yuka Moriguchi
Visiting Scholar